Human Genetics  BIOL 10700:  Fall 2010

Tuesday, Thursday, 2:35-3:50 p.m.

Williams 225







Dr. Marina Caillaud Office Hours: 
  • Tuesday 4-5:15 p.m.
  • or by appointment (e-mail me!)







Required:

1. Human Genetics and Society, 1st edition, by Yashon and Cummings (ISBN 0-495-11425-1).





  2.  A clicker handset



Visit this website EVERY WEEK for:  updates of the schedule, ppt notes, and links to potentially interesting websites.





Course Description:

Genetics is the study of inherited variation and traits. Although genetics is often associated with disease, our genes provide a great variety of characteristics that create much of our individuality, from our hair and eye color, to the shapes of our body parts, to our talents and personality traits. In February of 2001, the sequence of the human genome was completed. It will take much of the 21st century to understand our genetic selves. The potential impact of this new understanding is immense and raises many issues. Genetics affects our lives so intimately! Genetic tests can establish identity and diagnose disease. Do we want to know how and when we are likely to die or the predicted life expectancy of the baby we carry? Principles of genetics also touch history, politics and economics. For instance, genetic manipulations can provide new agricultural variants. Are these genetically modified plants safe to eat? Are they safe for the environment?


As young adults, citizens and voters, or simply parents, you will have to face during your lifetime many of these issues. The objective of this course is to provide you with a basic understanding of genetics, and especially human genetics, so that you can:

Course goals

 

By the end of this course, you should be able to:

  1. Understand the basic mechanisms of human inheritance and use this information to infer more complex concepts and solve basic genetics problems.
  2. Recognize several ways in which genetics influences daily life at the level of the individual and in society.
  3. Understand some of the basic tools used in genetic research and gain an appreciation for where our current understanding of genetics comes from.
  4. Demonstrate self-directed learning in genetics by identifying and utilizing credible resources available to the educated layperson.
  5. Effectively communicate genetics principles and issues in both written and oral forms.

Assessment

 

            The following are designed to test and ensure consistent progress on all five of the stated learning goals.

  1. Exams (60% total, 20% for each of the 3 in-class exams). Combination of multiple-choice and short answers. Assesses learning outcomes 1,3 and 5
  2. Homework assignments (15%). Throughout the semester, written assignments (in-class or not) will be graded. Assesses learning outcomes 1,2, 4, 5
  3. Final project (15%). Instead of an in-class final, you will be assigned a final paper and oral presentation on a genetics topic. This will be a group project. Further details will be provided later Assesses learning outcomes 4,5
  4. Class participation and attendance (10%).We will be using a clicker system on a daily basis (starting on September 7) which helps me to assess your understanding of the material, and to keep a record of attendance. Assesses learning outcomes 1,3

Grading scale:            


THERE IS NO EXTRA CREDIT


A : 94-100 A-: 90-93
B+ : 87-89 B :  84-86 B- : 80-83
C+ : 77-79 C :74-76 C- :70-73
D+ :67-69 D : 64-66 D- :60-63



S: below 70%
F : below 60%

Lecture PowerPoint presentations


I will post the PowerPoint presentations presented in lecture 24 h before the actual lecture. Note that these lectures notes are not complete, and are not intended to serve as a substitute to coming to class! I encourage you to print them before class, using for instances the many computer classrooms available to you on campus. This will greatly facilitate taking notes for this class.


Attendance policy

Students at Ithaca College are expected to attend all classes, and they are responsible for work missed during any absence from class. Students should notify their instructors as soon as possible of any anticipated absences, especially for examinations. Written documentation that indicates the reason for being absent may be required.

In accordance with New York State law, students who miss class due to their religious beliefs shall be excused from class or examinations on that day. Such students must notify their course instructors before any anticipated absence so that proper arrangements may be made to make up any missed work or examination without penalty.

Any student who misses class due to a verifiable family or individual health emergency or to a required appearance in a court of law shall be excused. The student or a family member/legal guardian may report the absence to the Office of Student Affairs and Campus Life, which will notify the student's dean's office, as well as residential life if the student lives on campus. The dean's office will disseminate the information to the appropriate faculty. Follow-up by the student with his or her professors is imperative. Students may need to consider a leave of absence, medical leave of absence, selected course withdrawals, etc., if they have missed a significant portion of classwork.

A student may be excused for participation in College-authorized cocurricular and extracurricular activities such as athletic events, musical and theatrical performances, and professional conferences.


Academic honesty


All work that you submit must be your own. Please familiarize yourself with the definition of plagiarism.


Academic dishonesty can lead to a zero grade on that assignment, a failing grade in the course, academic code probation, or suspension/expulsion from the college depending on the gravity of the violation and the decision of the judicial board.


In a collaborative project, all students in a group may be held responsible for academic misconduct if they engage in plagiarism or are aware of plagiarism by others in their group and fail to report it. Students who participate in a collaborative project in which plagiarism has occurred will not be held accountable if they were not knowledgeable of the plagiarism.


Course evaluations


Student input is highly valued and is important to maintain high quality instruction. Course evaluations are mandatory and must be completed by the indicated date (TBA). An incomplete will appear on your transcript if it is not submitted by that time. The evaluation will be submitted by the department Assistant. She will verify that you have submitted the form. Once that has been checked, your identification will be removed and will not be printed with the comments.


Students with disabilities


In compliance with section 504 of the Rehabilitation Act of 1973 and the Americans with Disabilities Act, reasonable accommodation will be provided to students with documented disabilities on a case by case basis. Students must register with the Office of Academic Support Services (607-274-1005, TDD 607-274-7319, acssd@ithaca.edu) and schedule an appointment with their instructors as soon as possible to discuss their needs.


Extra help and Support


Ithaca College provides a Counseling Center to support the academic success of students. The Counseling center provides cost-free services to help you manage personal challenges that threaten your well-being. The Health Center is also a resource on campus for students who experience a personal struggle.

Tentative schedule (may be subject to change)

 

Date
(by week)

Topic 

Digital Movie

Web links

Reading Assignment (Yashon & Cummings)

Aug 23

 

Introduction to Human genetics & the Cell (ppt notes)

 

 

The Eugenics movement in the US
Simple facts about DNA, RNA and inheritance

Careers in Genetics

Learning Center of Utah

Dolan Learning Center

Learning Center in Arizona

Cells Alive

Preview (pp. XXV-XXVII)

Biology Basics  : Cell and Cell Structure (pp. 1-5)

Aug 30

Sex and development (ppt notes)

 

Reproductive Technologies (ppt notes)


Cloning: Hot from the press
Ethics of cloning
Where you can clone your pets
Wilkipedia on cloning

The Visible embryo

Morphing embryos

Chap 1 AND pp. 44-45

 

Chap 2

 

Description of Cloning procedures

Stem Cells and cloning

Sept 6

How chromosomes (ppt notes)  and genes are transmitted (ppt notes)

 Meiosis

Chromosome 

More on Meiosis
../../../../../Webpage/cloning.pdfConsequences of Meiosis

A primer on Inheritance from Dolan

Catalog of Chromosomal Anomalies
Examples of Human Karyotypes

Genes and Health

Catalog of Human Genetic diseases

Rare diseases in Humans

Hemophilia
Finding genes affecting disease: Segment 12

 

Chap 3

 

Chap4

Sept 13

Extensions to Mendel   (ppt notes)

 

Multifactorial Inheritance (ppt notes)

 

Fat and happy . Look at the section "Thrifty gene"
More about Fat
Inheritance of eye color
Gender and female athletes (look at top left of the website you reach)
 Cat color genetics

Genes, Brain disorders and diseases

Behavior Genetics

Biology basics: genes, populations and environment

 

Chap 10

 

Chap 12

Sept 20

Review and Exam 1

 


Exam 1 is on Sept 23rd. Covers Lecs Aug 26-Sept 16

 

Sept 27

DNA Structure and Replication (ppt notes)

 

Transcription and Translation (ppt notes)

-DNA Structure
-DNA packaging

-DNA -Replication
-
Transcription

-Translation
-LacOperon

 

More on DNA Structure

More on gene expression

Virtual DNA extraction

A primer on DNA from Dolan

More about proteins and how they fold

 

Biology Basics: DNA

 

Chap 5

Oct 4 

 

Gene Mutation (ppt notes)

 

Biotechnology I (ppt notes)

 

-Gene Mutation
 -DNA repair

Types of Mutations, How do we get them

 

Chap 6

 

Oct 11

Biotechnology  II (ppt notes)

 

No class on Oct 14 –Fall break

 -Restriction enzymes
-Gel Electrophoresis
-DNA Restriction

-PCR
-Other PCR

More on Genetic Engineering
More on Recombinant DNA Technology

Discussing the safety of  GMO food

Problem sets in Recombinant DNA Technology

 

 

 

Oct 18

 

Review and Exam 2

 

 

Exam 2 is on Oct 21. Covers Lecs Sept 28-Oct 12

 

    Oct 25

 

Genetic testing (ppt notes)

 

DNA Forensics  (ppt notes)

 

 

 

Genetic Counseling I

Genetic Counseling II

A lot of info about the Human blood

A primer on Techniques in DNA forensics

Chap 7

 

Chap 8

Nov 1

 

The Human Genome Project, Human Populations and evolution (ppt notes)

 

 

 Cycle Sequencing

 

Department of Energy website on HUGO
The business side: Celera website

 What is race?

Database on Human Mutations

Database to explore Genomics Research

Chap 9

 

Chap 14

     Nov 8

 

Genetics of cancer (ppt notes)

 

Genetics of immunity (ppt notes)

 

Mitosis

Inside Cancer

A primer on the Immune system
How Lymphocytes produce antibodies

Simulating the spread of HIV

Autoimmune diseases

Chap 11

 

Chap 13

 

Nov 15

 

Review and Exam 3

 


Exam 3 is on Nov 18th . Covers Lecs Oct 26-Nov 11

 

Nov 22

 HAPPY THANKSGIVING 

Nov 29

 

Oral presentations by students

 

 

 

 

Dec 6

 

Oral presentations by students

 

 

 

 



Page maintained by Nancy Pierce.
Last updated 8/18/2010.