Fundamentals of Biology - Lecture Outlines: Chapter 11- Observable Patterns of Inheritance
Gregor Mendel
Garden Peas
Genetic Terms:
Gene
Locus
Diploid cells
Alleles
Homozygous
Heterozygous
Dominant
Homozygous dominant
Homozygous recessive
Two alleles separate during meiosis
Genotype
Phenotype
P
F1
Monohybrid Cross
Punnett Square method:
Cross Aa X Aa
Genotypic Ratio ____ AA: _____ Aa: _____aa
Phenotypic Ratio _____ purple : ______ white
Test-cross
2 different outcomes possible:
Dihybrid Cross:
- 2 traits
- assume they are on
Flower color and height
Purple
White
Tall
Short
Cross true-breeding parents
Purple tall X white short
What gametes can each parent produce?
What will be the genotype and phenotype of the offspring?
Cross: AaBb X AaBb
What gametes are produced?
How many possible combinations of eggs and sperm?
Draw the Punnett square for the cross.
What are the genotypic and phenotypic ratios of the offspring?
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Mendel's Theory of Segregation
- Diploid cells have pairs of genes
- on pairs of homologous chromosomes
- two genes of a pair separate
Mendel's Theory of Independent Assortment:
- At end of meiosis:
Genes on pairs of homologous chromosomes have been sorted out independent of genes on other chromosomes
Dominance Relations
Incomplete Dominance:
Example: Snapdragons: red X white --> pink
Codominance
Example: ABO blood typing
- (also a multiple allele system)
Blood types (Fig. 11.11):
Phenotype: Genotype(s)
A :
AB :
B :
O :
Pleiotropy
"more" + "change"
- Example - Marfan Syndrome
-loose jointed
- abnormally curved spine
Epistasis
Example: Hair Color in Mammals
- Black, yellow and chocolate labrador retrievers
Gene 1 = codes for melanin
- BB or Bb
- bb
Gene 2 - codes for deposition of melanin in hairs
- EE or Ee
- ee
Gene 3 - codes for tyrosinase (enzyme in melanin pathway)
- CC or Cc
- cc
Consider first 2 genes
Cross true-breeding black dog X yellow dog
F1 =
Now cross the offspring (F1 X F1 ) BbEe X BbEe
Another example of epistasis
Comb shape in poultry
Continuous Variation
Environmental Effects
Review
- Review questions 1-5
-Self quiz 1-8
Critical Thinking Genetics Problems 1-15