Fundamentals of Biology - Lecture Outlines: Chapter 11- Observable Patterns of Inheritance

Gregor Mendel

Garden Peas

 

Genetic Terms:

Gene

Locus

Diploid cells

Alleles

 

Homozygous

Heterozygous

Dominant

Homozygous dominant

Homozygous recessive

Two alleles separate during meiosis

Genotype

Phenotype

P

F1

 

Monohybrid Cross

Punnett Square method:

 

Cross Aa X Aa

 

 

Genotypic Ratio ____ AA: _____ Aa: _____aa

Phenotypic Ratio _____ purple : ______ white

 

 

 

Test-cross

 

2 different outcomes possible:

 

 

 

 

Dihybrid Cross:

- 2 traits

- assume they are on

Flower color and height

Purple

White

Tall

Short

 

Cross true-breeding parents

Purple tall X white short

 

What gametes can each parent produce?

What will be the genotype and phenotype of the offspring?

 

 

Cross: AaBb X AaBb

 

What gametes are produced?

How many possible combinations of eggs and sperm?

Draw the Punnett square for the cross.

What are the genotypic and phenotypic ratios of the offspring?

 

 

 

 

 

 

****************

Mendel's Theory of Segregation

- Diploid cells have pairs of genes

- on pairs of homologous chromosomes

- two genes of a pair separate

Mendel's Theory of Independent Assortment:

- At end of meiosis:

Genes on pairs of homologous chromosomes have been sorted out independent of genes on other chromosomes

 

Dominance Relations

Incomplete Dominance:

 

Example: Snapdragons: red X white --> pink

 

Codominance

 

 

Example: ABO blood typing

- (also a multiple allele system)

 

Blood types (Fig. 11.11):

Phenotype: Genotype(s)

A :

AB :

B :

O :

 

 

Pleiotropy

"more" + "change"

- Example - Marfan Syndrome

 

-loose jointed

- abnormally curved spine

 

Epistasis

 

 

Example: Hair Color in Mammals

- Black, yellow and chocolate labrador retrievers

Gene 1 = codes for melanin

- BB or Bb

- bb

Gene 2 - codes for deposition of melanin in hairs

- EE or Ee

- ee

Gene 3 - codes for tyrosinase (enzyme in melanin pathway)

- CC or Cc

- cc

Consider first 2 genes

 

Cross true-breeding black dog X yellow dog

 

F1 =

 

Now cross the offspring (F1 X F1 ) BbEe X BbEe

 

 

 

 

 

 

Another example of epistasis

Comb shape in poultry

 

Continuous Variation

 

 

 

Environmental Effects

 

Review

- Review questions 1-5

-Self quiz 1-8

Critical Thinking Genetics Problems 1-15