Fundamentals of Biology: Lecture Outline

Chapter 8 - How cells release stored energy

Cellular Respiration

- aerobic

- anaerobic

 

Aerobic Respiration

Summary Equation:

glucose + oxygen -----> carbon dioxide + water

 

3 series of Reactions:

  1. Glycolysis
  2. Prep. steps + Kreb's Cycle
  3. Electron Transport Phosphorylation

 

Glycolysis

 

- enzymes in

    1. Add phosphate to glucose
    2.  

    3. Enzymes remove hydrogen ions and electrons from PGAL
    4.  

       

    5. "Substrate level phosphorylation"

 

At the end of glycolysis you have:

- two 3 carbon pyruvates

- net gain of

 

Preparatory Steps

    - pyruvate enters mitochondrion

      - is converted to

      - gives off

      - gives up hydrogens and electrons

       

Kreb's Cycle

    - acetyl-CoA joins oxaloacetate

    - forms 6 carbon

      - cycle occurs twice

      - 3 carbons enter

      - 3 carbons leave

     

Functions of the cycle:

    - transfer hydrogen ions and electrons

      - produce

      - rearrange intermediates into

     

 

Summary of Coenzymes Produced:

Glycolysis

Pyruvate conversion

Kreb's Cycle

TOTALS

 

Electron Transport Phosphorylation

 

 

 

Chemiosmotic Model of ATP production

 

How do we get 36 ATP out of all this?

- 4 ATP form directly from

- 32 ATP form in E.T.P.

 

- for every NADH

 

 

- for every FADH2

 

 

In cells - 36 ATP

In heart, liver and kidney cells - 38 ATP

- difference is ATP yield from NADH formed in glycolysis

 

 

Anaerobic Routes

 

1. Lactate Fermentation

NET YIELD =

 

2. Alcoholic Fermentation (in yeast)

 

 

NET YIELD

3. Anaerobic Electron Transport

 

Alternative sources of energy:

- excess glucose intake is stored as:

Energy storage:

- 1%

- 78%

- 21%

 

Energy from fats:

 

 

 

Energy from proteins:

 

 

 

Review

Review questions 1-7

Self quiz 1-9