Genetics (BIOL-22700)
Lecture Syllabus

Spring 2008 May 14 Grades

Lectures Tu-Th   9:25-10:40 a.m
112 CNS
Note:I may be slightly behind or ahead this schedule of lectures

Instructor: Teaching Assistant	Marina Caillaud Lei Mi-Mi
Office:	Marina: 165 CNS Lei Mi-Mi: 179 CNS
Office hours:	Marina: Tuesday 4-5:30 Lei Mi-Mi: Review session Sunday 4-5:30 pm CNS 163
e-mail:	mcaillaud@ithaca.edu lmi1@ithaca.edu

Date (by week)	Topic	Movie/Animation/Web link	Reading assignment (read   BEFORE class)	Problems assignments (Try  AFTER class)
1/22	1. Cellular Reproduction (ppt notes)	A movie about the glamourous (!) life of cell biologists beautiful cells! Meiosis Mitosis Meiosis and Mendel independent assortment	-Chap 1 -Chap 2 (skip control of cell cycle, sexual reproduction in plants) -Genome: Introduction (read after lecture)	HOW TO STUDY FOR THIS COURSE Chap 2: 20, 22, 23, 25, 26, 29,27, 31, 33, 34
	2. Mendelian Genetics  (ppt notes)	DNA from the beginning Mendel and Monohybcross Dihybrid cross	-Chap 3: 47-62 -Genome: History (read after lecture)	STUDY GUIDE FOR lecs 2-4 Chap 3: worked problem 1,2; 12,13, 18,19, 22,23 Interactive CD: Problem 2 and 6 in menu  "Chromosomal Theory of Inheritance" submenu "Flylab", problem 6 in menu "Mendelian Analysis" submenu "Mendelian Problems" (disregard last question).
1/29	3. Sex-linked Inheritance (ppt notes)	white eyes in flies	-Chap 3: 62-74 -Chap 4	Chap 3: worked problem 3, 4; 24, 29, 34,36,38 Chap 4: worked problem 2 and 4. Problems 20, 21,  23,  27,  28, 31,  36,  39,  40
	4.Special case: Human Genetics (notes: ppt file) (notes: pdf file)	ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM www.yourgenesyourhealth.org/ygyh/mason/index what is Hemophilia http://www.pbs.org/(Movie Segments 3, 9, 10, 13 and 15). eugenics movement	-Chap 6 (except 156-159) -Genome: Fate AND Intelligence AND Pre-history (read after lecture)	Chap 6: Worked problems 1 and 2. Problems 12, 14, 16. Interactive CD: problems 1 and 4 in menu "Mendelian Analysis" submenu "pedigree and probabilities", problem 4 in menu "Chromosomal Theory of inheritance" submenu "X-linked inheritance", Problem 2 in Menu "Genotype/Phenotype" (disregard part c)
2/5	5.Extensions (ppt notes)	incomplete dominance http://anthro.palomar.edu/blood/default.htm	-Chap5: 101-end -Chap 6: pp. 156-159 -Genome: Environment AND Disease AND Sex (read after lecture)	STUDY GUIDE FOR lecs 5-7 Chap 5: worked problem 2 and 3;  problems 12, 16, 17, 20, 23, 28, 32, 34 Interactive CD: problem 4 and 6  in menu "Genotype/Phenotype"
	6. Linkage and Mapping I (ppt notes)	Crossing over Proof of genetic exchange	Chap 7: 160-175
2/12	7. Linkage and Mapping II		Chap 7: 175-end	Interactive CD:  problems 1, 3 and 4 in menu "Linkage" Chap 7: worked problem 1, 3, 4, 25.. Problems 13, 14, 19, 22, 25,
	8. DNA Structure (ppt notes)	Hersey Chase expt DNA is the genetic material Nucleic acids tutorial	-Chap 10 -Genome: Life (read after lecture)	Chap 10: worked problem 1, problem 26, 27, 30, 32,33
2/19	9. EXAM I (the exam will take place in CNS 107 and CNS 109-i.e. lab classes)	KEY EXAM 1		Exam 1 from previous years Look at the lab1-4 exercises Supplementary exercises (if you have time after looking at book Problems)
	10.Chromosome Structure (ppt notes)	Supercoil of DNA	Chap 11	Study Guide lec 10 none
2/26	11.DNA Replication (ppt notes)	DNA Polymerization Lagging/Leading DNA replication tutorial	-Chap 12 -Genome: Immortality (read after lecture)	Study Guide lecs 8 and 11 Chap 12: Worked problem 1. Problems 16, 17, 21, 22
	12.  Transcription  (ppt notes)	Transcription RNApolymerization Transcription tutorial More transcription tutorial	-Chap 13	Study Guide for lecs 12 and 13 Chap 13: worked problems 1 and 2. Problems 17, 18, 21, 23, 28, 33, 35, 38
3/4	13. RNA Processing (ppt notes)	Overview Processing Splicing introns	-Chap 14: 372-389	Chap 14: worked problems 2 and 3. Problems 20, 22, 24, 34 and 35 Interactive CD: Problem 1 and 3 in menu  "Molecular Biology" submenu "Gene Expression".
	14. Translation  (ppt notes)	translation tutorial networking proteins TranslationInitiation TranslationElongation TranslationTermination	Chap 15	MORE PROBLEMS for Practice Chap 15: worked problems 1 and 3. Problems 18, 25, 28, 29, 30,
3/11	.no class (spring Break)	HAVE FUN!!!!!!
3/18	15.Regulation of gene expression I (ppt notes)	Lac Operon Regulation Jacob and Monod Lac Repressor Lac Operator	-Chap 16: 433-447 -Genome: Stress (read after lecture)	Chapter 16: Worked Problem 3 . Problem 20, 22, 24, 27
	16.Regulation of gene expression II (ppt notes)	RNAi Steroid induction	Chap 16: 454-end	Chapter 16: problem 36, 37
3/25	17.  EXAM  II (the exam will take place in CNS 107 and CNS 109-i.e. lab classes)	Key for Exam 2		Exam 2 from previous years Supplementary exercises
	18.Genetic Engineering I (ppt notes)	www.ucsusa.org/index.cfm DNA Restriction Southern Hybridization Another Southern Gel Electrophoresis DNA TRansformation PCR DNA Library Screening a library	- Chap 18: pp. 509-517 -Chap 18: pp.517- 529 and pp. 530-532 (PCR only) -Genome: Cures (read after lecture)	Chap 18:worked problem 1. Problems 30, 32 and 34, 35,36,37, 38, 39
4/1	19.  no lecture!!
	20. Genetic engineering II	Cycle Sequencing	Chap 19: pp. 557-560 (DNA Sequencing methods)	Chap 19: worked problem 2, problem 25, and 26
4/8	21. Applications of genetic engineering  (ppt notes)	dnapatent.com/science/index.html More on Gene Therapy www.ornl.gov/hgmis/ bioethics.net/ DNA fingerprinting (click on DNA Detective) RFLP Analysis Application of PCR for DNA fingerprinting (click on Polymerase Chain Reaction )	-Chap 18, pp.538-545 -Genome : Prevention (read after lecture)	Chap 18: Problems 40, 41, 42 and 43 Interactive CD:  problems 1, 3 (part a only), 5, 6 in menu "Molecular Markers". Problem 3 in Menu 'Molecular Biology" submenu "Gene Expression". Problem 2, 3 and 4  in Menu "Molecular Biology" submenu 'Gene Cloning".
	22. Developmental Genetics (ppt notes). GUEST LECTURE BY MARC SERVETNICK
4/15	23. Genomics I (ppt notes)	ShotGun Sequencing www.celera.com A look at Chromosome 11 Metagenomics in the oceans (Sorcerer Expedition)	-Chap 19: 552-566 -Genome: Species AND Free Will (read after lecture)	Chap 19:worked problems 1 and 2; problems 23, 25,
	24. Genomics II	Microarray analysis Another animation on Microarrays	Chap 21: 608-619 -Chap 19: 567-581	Chap 19: 27, 31, 34
4/22	25. EXAM  III (the exam will take place in CNS 107 and CNS 109-i.e. lab classes)			Look at the lab 10 and lab 12 exercises Exam 3 from previous years Supplementary exercises
	26. Gene Mutation and DNA Repair (ppt notes)	The AmesTest Genetic Screen archive.uwcm.ac.uk/uwcm/mg/hgmd0.html Mutation because of 5 BU	Chap 17
4/29	27. Genetics of Cancer (ppt notes)	Regulation of Cell growth p53 gene	-Chap 21: 627-637 -Genome: Death
	28. Chromosome Mutation (ppt notes)	NonDisjunction Meet Pam, a woman who is part X0, part XY! Trisomy 21 anthro.palomar.edu/abnormal/default.htm U of Washington cytogallery Inversion Translocation	Chap 9	Chapter 9: 19, 37, 40, 41
5/9	Final exam Take-home Final exam due at 2 pm in CNS 112.  YOUR Presence is mandatory.
	HAVE A GREAT SUMMER

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Page maintained and updated by Marina Caillaud
Last updated May 14, 2008