About this blog
Newest kudos -- Leann and former students' paper is published! Maki and students' work is published!; Andy Smith and his lab gets published; Dave Gondek is in print
Tuesday, April 18, 2017
Hot off the press!
Kanda, L.L, A. Abdulhay, and C. Erickson. 2017. Adult wheel access interaction with activity and boldness personality in Siberian dwarf hamsters (Phodopus sungorus). Behavioural Processes 138:82-90. View the article here.
Student co-authors. Amir (Biology ’11) and Caity (Biology ’12).
Thursday, October 20, 2016
Inada M, *Nichols RJ, Parsa JY, Homer CM, *Benn RA, *Hoxie RS, Madhani HD, Shuman S, Schwer B, Pleiss JA. Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast. Nucleic Acids Res. 2016 Jul 8. pii: gkw603. [Epub ahead of print]
* IC undergraduates
Thursday, October 8, 2015
Alex M. Wilks (’15), Sarah R. Rabice(’14), Holland S. Garbacz (’15), Cailin C. Harro (’17), Andrew M. Smith. 2015. Double-network gels and the toughness of terrestrial slug glue. Journal of Experimental Biology 218, 3128-3137; doi: 10.1242/jeb.128991 View the article here.
Monday, June 22, 2015
Georg Stary, Andrew Olive, Aleksandar F. Radovic-Moreno, David Gondek, David Alvarez, Pamela A. Basto, Mario Perro, Vladimir D. Vrbanac, Andrew M. Tager, Jinjun Shi, Jeremy A. Yethon, Omid C. Farokhzad, Robert Langer, Michael N. Starnbach, Ulrich H. von Andrian. (2015). A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells. Science (348) 6241. DOI: 10.1126/science.aaa8205.
Genital Chlamydia trachomatis (Ct) infection induces protective immunity that depends on interferon-γ–producing CD4 T cells. By contrast, we report that mucosal exposure to ultraviolet light (UV)–inactivated Ct (UV-Ct) generated regulatory T cells that exacerbated subsequent Ct infection. We show that mucosal immunization with UV-Ct complexed with charge-switching synthetic adjuvant particles (cSAPs) elicited long-lived protection in conventional and humanized mice. UV-Ct–cSAP targeted immunogenic uterine CD11b+CD103– dendritic cells (DCs), whereas UV-Ct accumulated in tolerogenic CD11b–CD103+ DCs. Regardless of vaccination route, UV-Ct–cSAP induced systemic memory T cells, but only mucosal vaccination induced effector T cells that rapidly seeded uterine mucosa with resident memory T cells (TRM cells). Optimal Ct clearance required both TRM seeding and subsequent infection-induced recruitment of circulating memory T cells. Thus, UV-Ct–cSAP vaccination generated two synergistic memory T cell subsets with distinct migratory properties.
Wednesday, July 3, 2013
Melcher P, and Zwieniecki MA. (2013). Functional analysis of embolism induced by air injection in Acer rubrum and Salix nigra. Frontiers in Plant Biophysics and Modeling. Link to more information here.
Maciej A. Zwieniecki, Peter J. Melcher, and Eric T. Ahrens (2013). Analysis of spatial and temporal dynamics of xylem refilling in Acer rubrum L. using magnetic resonance imaging (MRI). Frontiers in Plant Biophysics and Modeling. doi: 10.3389/fpls/2013.00265.