| Dr.
Andrew Smith |
Lecture: TR 1:10-2:25 Discussion T 2:25-3:25 CNS
119
Office
Hours: M
4-5, T 9-10
|
Text: As noted above, there is no required text for this class. Most of your reading will consist of primary research reports. It would be helpful to have an animal physiology text available as a reference, though.
| Course Description | Academic Honesty |
| Goals and Outcomes |
Grades |
| Course Requirements |
Students with Disabilities |
This
course will explore hormonal control,
emphasizing current research. Lectures
will give background on the key concepts, then they will focus on
in-depth analysis
of the major vertebrate hormones using published research.
We will study topics such as gender
differentiation, growth, reproduction, weight control, diabetes, the
stress
response, and other areas of current interest.
The lectures will emphasize discussion and analysis of the
scientific
literature. The discussion period will
provide time for more in-depth writing exercises, discussions and
occasional
demonstrations.
The reasons for using the scientific literature instead of a more typical, textbook-based lecture approach are four-fold:
The methods of endocrinology are the methods of modern molecular biology – they are the tools of the 21st century. It’s a good idea to learn their power and limitations.
Course goals and learning outcomes:
Attendance and participation: Because this class depends on interaction, attendance is expected as is regular contribution to the class discussions. If you will be unable to attend a class, notify me in advance (I check e-mail and voice-mail regularly). Students will be expected to contribute to class discussions, and everyone will be called on with regularity to respond to questions related to assignments or discussions. You will not be called on unless you have had a chance to prepare. Your grade will not be affected by whether you are right, only on whether you are prepared and have made a reasonable attempt to answer the question.
Graded writings: There will be at least one writing assignment each week. The writing assignments will focus on analysis (goals 3 - 6). There will also be a few quizzes early in the semester to test required background information (goals 1 + 2). Writings may involve analyzing or commenting on a scientific paper or specific elements of a paper, suggesting further experimental approaches, or considering the broader implications of some finding. You will not be expected to memorize the details of any particular experimental study.
Ungraded writing assignments: There will be additional, informal writings that will be used to stimulate your thoughts on specific topics.
Review paper: You will write an extended paper on an endocrinology topic of your choice. Your grade will depend on thoroughness, clarity, quality analysis and depth of understanding. These papers are typically 10+ pages and typically review 10-20+ primary sources. The paper will be written in stages, and will be peer-reviewed, with parts of the grade assigned at specific stages.
Presentations: Each week a group of 2-3 students will be responsible for preparing an oral presentation of a paper we are reading. The presentations should be brief (roughly 10 min) and focused. You will not be graded on the presentation style – instead, you will submit your Powerpoint, which will be graded for clarity, focus and depth of understanding.
Final: The final will be a graded writing like the other ones throughout the semester, and will be counted in with the rest.
| Graded writings and quizzes | 55% |
| Review paper | 25% |
| Presentation |
10% |
| Class
participation |
10% |
Grades
will be given based on whether the student met the expectations
of the assignment, using a scale of 0 – 3 as follows:
0 = No evidence of achieving goal. The work was either not done, or done so poorly that one cannot discern sufficient progress towards achieving the goal.
1 = Approaches goal. The guidelines of the assignment were followed and the work shows evidence of progress towards meeting the goal. Nevertheless, it may be unclear, partially incorrect, or reflect misunderstandings.
2 = Meets goal. The work is performed with minimal errors or misunderstandings and is of overall good quality. It could be improved, however, with increased analysis, integration, sophistication or rigor.
3 = Exceeds goal. Performs the
task at the level expected of an
experienced scientist. There are no
significant errors or misunderstandings, the work is clear and
comprehensive,
and it demonstrates sophisticated thinking (insight, analytical
ability,
integration etc…).
These grades correlate loosely to letter grades as follows:
A Meets the goals of almost all assignments, occasionally exceeding the goals (2.3+)
A-/B+ Meets the goals of all assignments (~2)
B Meets the goals of most of the assignments (~1.7+)
C Typically approaches goals, only occasionally meeting them (~1.3)
D Approaches the goals roughly half of the time (~0.5)
F No
evidence
of achieving goals (<
0.5)
I take into account progress over the semester. I typically expect students to have more trouble meeting the goals early in the semester, but as their skills develop, they can meet the goals more easily. Demonstrating full ability to meet the goals at the end of the semester carries a lot of weight in the grading.
Student input is highly valued and is important to maintain high quality instruction. Course evaluations are mandatory. They will be administered on-line at the end of the semester. You will get a zero for a homework assignment if it is not completed by the due date. The evaluation will be submitted to the Department Assistant. She will verify that you have submitted the form.
|
Week |
Lecture |
Discussion topic |
|
1/20 |
Introduction, course overview, what determines hormone function Hormone/receptor interactions |
IGF’s, milk and cancer – evaluating evidence |
|
1/27 |
Overview of major hormones, feedback control of hormone levels Hormone classes, complexity of hormonal control |
Estrogenic chemicals and mouse genetics |
|
2/3 |
Experimental methods Experimental methods |
Histology of glands |
|
2/10 |
Thyroid hormones and metabolism Diabetes |
|
|
2/17 |
Weight control / energy balance |
|
|
2/24 |
Energy balance and reproduction |
|
|
3/3 |
Hormonal signals that trigger reproduction or reproductive development |
|
|
3/10 |
-- Spring Break -- |
-- Spring Break -- |
|
3/17 |
Gender differentiation / hormones and reproductive behavior |
|
|
3/24 |
Hormones controlling labor and childbirth |
|
|
3/31 |
Environmental chemicals that disrupt reproductive hormonal control |
|
|
4/7 |
Growth hormone, IGF’s and aging |
|
|
4/14 |
Hormonal control of bone density |
|
|
4/21 |
Evolution of the blood pressure / salt balance control system |
|
|
4/28 |
Hormones and the stress response |
|