About this blog
Newest kudos -- Dave Gondek is in print; Paul De Luca's work is IN PRESS!; Leann and John Confer's works is accepted; Jean, Maki, Andy, and Peter's work is published!
Monday, June 22, 2015
Georg Stary, Andrew Olive, Aleksandar F. Radovic-Moreno, David Gondek, David Alvarez, Pamela A. Basto, Mario Perro, Vladimir D. Vrbanac, Andrew M. Tager, Jinjun Shi, Jeremy A. Yethon, Omid C. Farokhzad, Robert Langer, Michael N. Starnbach, Ulrich H. von Andrian. (2015). A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells. Science (348) 6241. DOI: 10.1126/science.aaa8205.
Genital Chlamydia trachomatis (Ct) infection induces protective immunity that depends on interferon-γ–producing CD4 T cells. By contrast, we report that mucosal exposure to ultraviolet light (UV)–inactivated Ct (UV-Ct) generated regulatory T cells that exacerbated subsequent Ct infection. We show that mucosal immunization with UV-Ct complexed with charge-switching synthetic adjuvant particles (cSAPs) elicited long-lived protection in conventional and humanized mice. UV-Ct–cSAP targeted immunogenic uterine CD11b+CD103– dendritic cells (DCs), whereas UV-Ct accumulated in tolerogenic CD11b–CD103+ DCs. Regardless of vaccination route, UV-Ct–cSAP induced systemic memory T cells, but only mucosal vaccination induced effector T cells that rapidly seeded uterine mucosa with resident memory T cells (TRM cells). Optimal Ct clearance required both TRM seeding and subsequent infection-induced recruitment of circulating memory T cells. Thus, UV-Ct–cSAP vaccination generated two synergistic memory T cell subsets with distinct migratory properties.
Friday, December 5, 2014
2014 De Luca, PA, Stoltz, JA, Andrade, MCB & Mason, AC. Metabolic efficiency in courtship favors males with intermediate mass in the Australian redback spider, Latrodectus hasselti. Journal of Insect Physiology. In press.
Recent studies have suggested that metabolic efficiency may be an important factor in male mating success when females require vigorous and/or prolonged courtship. In capital breeding animals in which a male’s resource pool is fixed at adulthood the relationship between energy expenditure and courtship performance may be especially important, as males are expected to utilize their finite resources efficiently when soliciting mates. Males may benefit from being efficient, i.e., achieving a sufficiently high level of courtship signaling at low energetic cost, if it enables them to acquire mates before their limited energy reserves are depleted. We investigated the relationship between metabolic efficiency and courtship vibrational signaling in the Australian redback spider, Latrodectus hasselti, a semelparous capital breeder where males invest heavily in courtship to secure a mating. We assessed metabolic rate in a sample of males and measured two courtship components (duty cycle and amplitude) that reflected the energy content of web-borne vibrations. We then calculated two indices of metabolic efficiency for these courtship properties. There was a quadratic relationship between mass and duty cycle such that the highest duty cycle signals were performed by males having intermediate mass. Furthermore, intermediate-mass males were also the most metabolically efficient. Prolonged courtship is necessary in L. hasselti for successful mating, and the results of this study suggest that intermediate-mass males are superior courters because they utilize their finite resource pool most efficiently to produce high energy vibrational signals.
Friday, March 14, 2014
John Confer, Leann Kanda, and Ireyena Li (recent ENVS graduate). Accepted March 2014. “Northern Saw-whet Owl regional patterns for fall migration and demographics revealed by banding data” accepted for publication in the Wilson Journal of Ornithology.
Monday, November 4, 2013
Jean C. Hardwick, Shannon E. Ryan (’12), Eric Beaumont, Jeffrey L. Ardell, E. Marie Southerland, Dynamic remodeling of the guinea pig intrinsic cardiac plexus induced by chronic myocardial infarction, Autonomic Neuroscience, Available online 31 October 2013, ISSN 1566-0702, http://dx.doi.org/10.1016/j.autneu.2013.10.008.
Wednesday, July 3, 2013
Melcher P, and Zwieniecki MA. (2013). Functional analysis of embolism induced by air injection in Acer rubrum and Salix nigra. Frontiers in Plant Biophysics and Modeling. Link to more information here.
Maciej A. Zwieniecki, Peter J. Melcher, and Eric T. Ahrens (2013). Analysis of spatial and temporal dynamics of xylem refilling in Acer rubrum L. using magnetic resonance imaging (MRI). Frontiers in Plant Biophysics and Modeling. doi: 10.3389/fpls/2013.00265.