Jean Hardwick

Dana Professor and Chair, Biology
School: School of Humanities and Sciences


My Research

My research focuses on neuronal regulation of cardiac function. Specifically, I am interested in how neurotransmitters (chemicals released by nerve cells to communicate with one another) can modulate the activity of neurons located within the heart which in turn regulate heart rate and the strength of heart contractions. To investigate these questions, I make use of several different neurobiological techniques, including immunohistochemistry, electrophysiology, and biochemical techniques. Currently, I'm investigating two specific questions.

My previous studies have demonstrated that the immune system can interact with neurons that control cardiac function.  For example, an allergic reaction involving the heart (cardiac anaphylaxis) appears to directly affect the activity of neurons located within the heart itself.  For our current work, we are expanding this question to ask how chronic heart disease, which would include increased stimulation of the immune system as well as the sympathetic nervous system, can alter neuronal function.  More specifically, we hypothesize that chronic heart disease, such as occurs with myocardial infarction (blockage of coronary blood vessels) or pressure overload (which could occur with chronic hypertension) leads to a remodeling of the intrinsic cardiac nervous system.  To study this, we use animals with models of chronic heart disease and examine the electrical responses of these neurons to neurotransmitters, neuropeptides and other bioactive signalling molecules.  Our preliminary studies indicate that chronic heart disease alters the sensitivity of these neurons to specific chemicals, which may result in an increased ability of the nervous system to reduce cardiac activity.

In addition to changes in electrical activity, we are also looking for changes in protein expression in these neurons with disease.  Specific proteins appear to be upregulated with disease and we can measure these changes with standard biochemical techniques, such as Western blots and PCR to detect mRNA.

To learn more about one of my student's research, click this link to see a video slide show about the lab!

Two girls pipetting in a lab

Involvement in Brain Initiative Research

I was one of 25 neuroscientists from across the country invited to a workshop focusing on increasing PUI involvement in NSF-funded BRAIN initiative research. This workshop, sponsored by the National Science Foundation, explored ways to increase the involved of undergraduate institutions in the President Obama's BRAIN initiative.  This initiative looks to advance research in our understanding of the brain.  The participants in this workshop spent two days exploring ways that institutions, like Ithaca College, could participate in this important discovery process and several potential grant initiatives were discussed and will hopefully be submitting in the coming months.

During this meeting my student, Katie Luckett, presented research conducted in my lab. 

National Institutes of Health AREA R15; 2016-2020, “Peptidergic modulation of the guinea pig cardiac plexus with chronic heart disease", $365,845

It supported research on the role of neuropeptides in the remodeling of the cardiac nervous system with heart disease.  My students and I examined the changes induced by chronic heart disease in an animal model of myocardial infarction (or a heart attack) to determine how specific signaling molecules are changing and whether these changes are contributing to the pathology of the disease, or acting to improve cardiac function.  The NIH grant allowed the lab to purchase new equipment for sophisticated electrical recordings from neurons, as well as funded student research opportunities during the summers.