Faculty

Albertelli L*, Jallow S*, Li C, Ulrich SM. Structural reassignment of compound 968, an allosteric glutaminase inhibitor. Beilstein J. Org. Chem. 2026, 22, 455–460. link to paper

Crane CS*, McIssac TK*, Milano SK, Cerione RA, Ulrich SM. Structure and enzymology of glutaminase mutants that disrupt glutamine-glutamate homeostasis and cause neurological disease. BioRxiv 2025 link to paper

Madhavan SS, Roa Diaz S, Peralta S, Nomura M, King CD, Ceyhan KE, Lin A, Bhaumik D, Foulger AC, Shah S, Blade T, Gray W, Chamoli M, Eap B, Panda O, Diaz D, Garcia TY, Stubbs BJ, Ulrich SM, Lithgow GJ, Schilling B, Verdin E, Chaudhuri AR, Newman JC. β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain. Cell Chemical Biology. 32, 1, 16 January 2025 , pp 174-191. link to paper

Crane C*, Miele M*, Iyengar R*, Strathmann N*, Jallow S*, Ulrich S. Erastin-like anti-Warburg compounds X1 and X4 are GLS2-selective covalent glutaminase inhibitors. ChemRxiv . 2024 ; doi:10.26434/chemrxiv-2024-mtk6s link to paper

Newman JC, Keran Ma, Kroll F, Higgins E*, Ulrich S, Palop JJ, Verdin E. Small-molecule ketone esters treat brain network abnormalities in an Alzheimer’s disease mouse model. BioRxiv 2022 . doi: 10.1101/2022.09.24.509337 link to paper

Higgins E*, Kellner-Rogers JS*, Estanislau AM*, Esposito AC*, Vail NR*, Payne SR*, Stockwell JG*, and Ulrich SM. Design, synthesis, and evaluation of transition-state analogs as inhibitors of the bacterial quorum sensing autoinducer synthase CepI. Bioorganic and Medicinal Chemistry Letters Volume 39, May 1 , 2021 link to paper

Budin N*, Higgins E*, DiBernardo A*, Raab C*, Li C, Ulrich SM. Efficient synthesis of the ketone body ester (R)-3-hydroxybutyryl-(R)-3-hydroxybutyrate and its (S,S) enantiomer. Bioorganic Chemistry Volume 80, October 2018 , Pages 560-564 link to paper

Stalnecker CA, Ulrich SM, Li Y, Ramachandran S, McBrayer MK, DeBerardinis RJ, Cerione RA, Erickson JW. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc Natl Acad Sci U S A . 2015 Jan 13;112(2):394-9. link to paper

Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV Jr, de Cabo R, Ulrich S, Akassoglou K, Verdin E. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science . 2013 Jan 11;339(6116):211-4 link to paper

Chen A, Karolczak-Bayatti M, Sweeney M, Treumann A, Morrissey K, Ulrich SM, Europe-Finner GN, Taggart MJ. Lysine deacetylase inhibition promotes relaxation of arterial tone and C-terminal acetylation of HSPB6 (Hsp20) in vascular smooth muscle cells. Physiol Rep . 2013 Nov;1(6):e00127. link to paper

Karolczak-Bayatti M, Sweeney M, Cheng J, Edey L, Robson SC, Ulrich SM, Treumann A, Taggart MJ, Europe-Finner GN. Acetylation of heat shock protein 20 (Hsp20) regulates human myometrial activity. J Biol Chem . 2011 Sep 30;286(39):34346-55. doi: 10.1074/jbc.M111.278549. link to paper

Swem L, Swem D, O'Loughlin C* , Gatmaitman R* , Ulrich SM, Bassler B. A quorum sensing antagonist that targets both membrane-bound and cytoplasmic receptors controls bacterial pathogenicity. Molecular Cell 35 (2) 143-153, 31 July 2009 link to paper

Ulrich SM. Protein kinases and phosphatases: Chemistry and roles. Wiley Encyclopedia of Chemical Biology 2008 Link to paper

KrennHrubec K*, Marshal B, Hedglin M*, Verdin E and Ulrich SM. Design and evaluation of linkerless hydroxamic acids as selective HDAC8 inhibitors. 2007 March 30 Bioorganic and Medicinal Chemistry Letters link to paper

Prior to Ithaca College:

Su T, Bryant DM, Luton F, Vergés M, Ulrich SM, Hansen KC, Datta A, Eastburn DJ, Burlingame AL, Shokat KM, Mostov KE. A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol. 2010 Dec;12(12):1143-53. doi: 10.1038/ncb2118. Epub 2010 Oct 31.

Ulrich SM, Kenski DM, Shokat KM. Engineering a "methionine clamp" into Src family kinases enhances specificity toward unnatural ATP analogues. Biochemistry. 2003 Jul 8;42(26):7915-21. doi: 10.1021/bi030042a. PMID: 12834343.

Ulrich SM, Sallee NA, Shokat KM. Conformational restraint is a critical determinant of unnatural nucleotide recognition by protein kinases. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3223-7. doi: 10.1016/s0960-894x(02)00616-9.

Ulrich S, Shokat K. Green fluorescent protein-based protein kinase biosensor substrates. Methods Mol Biol. 2002;183:275-85. doi: 10.1385/1-59259-280-5:275.

Bishop A, Buzko O, Heyeck-Dumas S, Jung I, Kraybill B, Liu Y, Shah K, Ulrich S, Witucki L, Yang F, Zhang C, Shokat KM. Unnatural ligands for engineered proteins: new tools for chemical genetics. Annu Rev Biophys Biomol Struct. 2000; 29:577-606. doi: 10.1146/annurev.biophys.29.1.577.

Krow GR, Cheung OH, Hu Z, Huang Q, Hutchinson J, Liu N, Nguyen KT, Ulrich SM, Yuan J, Xiao Y, Wypij DM, Zuo F, Carroll, PJ. Nitrogen bridge homoepibatidines. syn -6- and syn -5(6-chloro-3-pyridyl) isoquinuclidines. Tetrahedron Volume 55, Issue 25, 18 June 1999, Pages 7747-7756